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KMID : 0882420050690000970
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Korean Journal of Medicine
2005 Volume.69 No. 0 p.970 ~ p.973
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A case of severe aplastic anemia induced by d-penicillamine in systemic scleroderma
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Lee Dong-Won
Lee Sun-Mi
Lee Jun-Hee
Sin Ho-Jin
Chung Joo-Seop
Cho Goon-Jae
Kim Sung-Il
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Abstract
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D-penicillamine has been used in treating systemic scleroderma (SSc) to reduce skin thickening and to prevent further involvement of internal organs. Well known side effects include skin rash, changes or loss of taste, nausea and vomiting, hematologic complications such as thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia and autoimmune disease such as Goodpasture’s syndrome, myasthenia gravis, polymyositis, and systemic lupus erythematosis. Aplastic anemia is a rare complication and is usually resolved by discontinuing medication.
We experienced a case of D-penicillamine-induced severe aplastic anemia in systemic scleroderma patient and would like to report this case with review of articles.(Korean J Med 69:S970-S973, 2005)
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KEYWORD
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D-penicillamine, Aplastic anemia, Systemic Scleroderma
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